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Dr. Christine Friedenreich
Research Scientist
Division of Population Health and Information
Tom Baker Cancer Centre
1331 – 29th Street N. W.
Calgary, Alberta T2N 4N2
E-mail: chrisf@cancerboard.ab.ca
Current Appointments
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Leader, Population Health Research |
Division of Population Health and Information
Alberta Cancer Board
Calgary, Alberta |
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Adjunct Professor |
Department of Community Health Sciences
Faculty of Medicine, Faculty of Kinesiology
University of Calgary
Calgary, Alberta |
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Scientific Staff |
Tom Baker Cancer Centre
Alberta Cancer Board
Calgary, Alberta |
Education and Training
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1992-1994 |
PDF |
Department of Community Health Sciences, University of Calgary, Faculty of Medicine
Calgary, Alberta |
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1990-1991 |
PDF |
Unit of Analytical Epidemiology, International Agency for Research on Cancer
Lyon, France |
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1986-1990 |
Ph. D. |
Epidemiology, University of Toronto Toronto, Ontario |
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1984-1986 |
M. Sc. |
Community Health and Epidemiology, Queen’s University Kingston, Ontario |
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1982-1984 |
Certificate |
French Language and Literature, Université de Lausanne
Lausanne, Switzerland |
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1978-1982 |
B. Sc. |
Life Sciences, Queen’s University Kingston, Ontario |
Overview of Research Program
Dr. Friedenreich’s research program focuses on cancer etiology primarily on the role of physical activity in cancer prevention, rehabilitation and survival. Her research has expanded to include studies of the biologic mechanisms that mediate the association between physical activity and cancer. She currently has an analysis of the Metabolic Syndrome in an endometrial cancer case-control study on-going and three cohort studies of physical activity in breast, prostate and endometrial cancer survival. She is also the principal investigator of the ALPHA Trial (Alberta Physical Activity and Breast Cancer Prevention Trial). This randomized control trial is examining the effect of aerobic exercise on intermediate biologic end points for breast cancer.
As a co-investigator, she is conducting studies of exercise as a means for coping, rehabilitation and improved quality-of-life after cancer diagnosis. Dr. Friedenreich is also interested in measurement of physical activity and dietary intake. She has developed the interview-administered Lifetime Total Physical Activity Questionnaire that has been used in her case-control studies. A self-administered version of the questionnaire, the Past Year Total Physical Activity Questionnaire, is currently being used in the Tomorrow Project , a cohort study in Alberta, and a validation study of the self-administered questionnaire has been conducted and published.
Currently Held Research Support
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Agency |
Project Title |
Investigators |
Total Funding |
Term |
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ACRI Breast Cancer Translational Group |
Breast Cancer to Bone (B2B) Metastases Program |
Friedenreich, CM
Magliocco, A
Brockton, NT
Paterson, A
Hanley, D
Vogel, H
Shemanko, C |
$1,402,890 |
2008-11 |
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ACRI Priority Funding |
Division of Population Health & Information; ACRI Priority Funding Request |
Friedenreich, CM
Kopciuk, K
Kelemen, L
Brockton, N |
$418,335 |
2008-11 |
| Alberta Cancer Foundation |
The Alberta Cohort Study (The Tomorrow Project): Infrastructure Support |
Robson, P
Friedenreich, CM
McGregor, E
Csizmadi, I
Kopciuk, K
Brockton, N
Kelemen, L
Bryant, H |
$500,000 |
2007-08 |
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CIHR |
Development of a multidimensional measure of activity energy expenditure for use in large populations |
Csizmadi, I
Robson, PJ
Bryant, HE
Friedenreich, CM
Jones, P
Kopciuk, K
Lau, DC |
$238,170 |
2008-10 |
| CBCRA |
Randomized controlled trial of combined aerobic and resistance exercise in breast cancer survivors receiving chemotherapy: The CARE Trial |
Courneya, KS
Segal, RJ
McKenzie, DC
Mackey, JR
Gelmon, K
Friedenreich, CM
Reid, R |
$946,646 |
2007-12 |
| ACB |
Population Health Research Unit, Division of Population Health & Information |
Friedenreich, CM
Bryant, HE
Cook, L
McGregor, SE
Kopciuk, K
Csizmadi, I |
$1,254,525 |
2007-10 |
| CIHR |
Eco-EUFORIA: Economic evaluation of using urban form to increase activity |
Sheill, A
Doyle-Baker, PK
Sandalack, BA
Auld, MC
Friedenreich, CM
Giles-Corti, B
Smithers, WL |
$593,643 |
2007-10
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CIHR |
Identifying and eliminating barriers to participation in physical activity and sport in cancer survivors |
Courneya, KS
Rhodes, RE
Blanchard, CM
Culos-Reed, SN
Friedenreich, CM
Mackey JR |
$52,591 |
2007-08 |
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ACB-RIP/NCIC |
Metabolic syndrome and lifestyle risk factors in endometrial cancer and survival |
CM Friedenreich, KS Courneya, LS Cook, I Csizmadi, AM Magliocco, DCW Lau, Y Yasui |
$333,412 / $186,050 |
2006-09 |
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Alberta Breast Cancer Research Initiative / CBCRA |
Alberta Physical Activity (ALPHA) and Breast Cancer Prevention Trial: an ancillary study examining androgens, biomarkers of obesity, and inflammation |
Friedenreich, CM
Courneya, KS
McTiernan, A
Irwin, ML
Jones, C
Yasui, Y |
$170,000 / $176,748 |
2006-08 |
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ACF |
Individual, social and environmental determinants of physical activity in an Alberta cohort |
Bryant, HE
Friedenreich, CM
Kopciuk, KA
Plotnikoff, R |
$19,696 |
2006-08 |
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NCIC
Centre for Behavioural Research and Program Evaluation |
Physical exercise across the cancer experience -- research team grant |
Courneya, KS
Friedenreich, CM
Quinney, HA
Fields, ALA
Mackey, JR
Parliament, MB
Sela, RA
Turner, AR |
$440,000 |
2003-08 |
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Lance Armstrong Foundation |
Effects of exercise training on quality of life in lymphoma survivors |
Courneya, KS (PI),
Reiman, T
Jones, LW
Friedenreich, CM
Fairey, AS |
$225,000 |
2005-08 |
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ACB-RIP |
Population Health Research Unit, Division of Population Health & Information |
Bryant, HE
Friedenreich, CM
McGregor, SE
Cook, LS
Brasher, P
Kopciuk, K
Csizmadi, I |
$340,000 |
2004-07 |
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CIHR and ACB |
Cohort study of physical activity and prostate cancer survival: continuation of follow-up |
Friedenreich, CM
Courneya, KS
McGregor, SE
Kopciuk, K
Angyalfi, SJ
Elliott, FG |
CIHR - $283,453
ACB - $40,244 |
2004-07
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Recent Publications (2002-present)
1. Friedenreich CM. Commentary: Improving Pooled Analyses in Epidemiology . Int J Epidemiol 2002;31:86-87.
2. Courneya KS, Friedenreich CM, Sela RR, Quinney HA, Rhodes RE. Correlates of Adherence and Contamination in a Randomized Controlled Trial of Exercise in Cancer Survivors: An Application of the Theory of Planned Behaviour and the Five Factor Model of Personality . Ann Behavior Med. 2002;24:257-268.
3. Friedenreich CM , Courneya KS, Bryant HE. Case-Control Study of Anthropometric Measures and Breast Cancer Risk. Int J Cancer 2002;99:445-452.
4. Glück S, Friedenreich CM. Clinical Approaches to Male Breast Cancer. Geriatrics and Aging. 2002;5:19-21.
5. Friedenreich CM , Orenstein MR. Physical Activity and Cancer Prevention: Etiologic Evidence and Biological Mechanisms . J Nutr. 2002;132:3456S-3464S.
6. Courneya KS, Friedenreich CM, Sela RR, Quinney HA, Rhodes RE, Handman M. The Group Psychotherapy and Home-Based Physical Exercise (GROUP-HOPE) Trial in Cancer Survivors: Physical Fitness and Quality of Life Outcomes . Psycho-Oncology 2003;12:357-374.
7. Courneya KS, Friedenreich CM , Quinney HA, Fields ALA, Jones LW, Fairey AS. A Randomized Trial of Exercise and Quality of Life in Colorectal Cancer Survivors. Eur J Cancer Care 2003;12:347-357.
8. Courneya KS, Jones LW, Fairey AS, Campbell KL, Ladha AB, Friedenreich CM , Mackey JR. Physical Activity in Cancer Survivors: Implications for Recurrence and Mortality . Cancer Therapy 2004;2:1-12.
9. Courneya KS, Friedenreich CM , Sela RA, Quinney HA, Rhodes RE, Jones LW. Exercise Motivation and Adherence in Cancer Survivors After Participation in a Randomized Controlled Trial: An Attribution Theory Perspective . Int J Behav Med 2004;11(1):9-18.
10. Friedenreich CM , McGregor SE, Courneya KS, Angyalfi SJ, Elliott FG. Case-Control Study of Lifetime Total Physical Activity and Prostate Cancer Risk. Am J Epidemiol 2004;159:740-749.
11. Friedenreich CM , McGregor SE, Courneya KS, Angyalfi SJ, Elliott FG. Case-Control Study of Anthropometric Measures and Prostate Cancer Risk. Int J Cancer 2004;110:278-83.
12. Friedenreich CM. Physical Activity and Breast Cancer Risk: the Effect of Menopausal Status. Exer Sci Sports Rev 2004;32(4):180-84.
13. Orenstein MR, Friedenreich CM. Review of Physical Activity and the IGF family. J Physical Activity and Health 2004;1(4):291-320.
14. Courneya KS, Friedenreich CM , Quinney HA, Fields ALA, Jones LW, Fairey AS. Predictors of Adherence and Contamination in a Randomized Controlled Trial of Exercise in Colorectal Cancer Survivors . Psychooncology 2004;13:857-66.
15. Courneya KS, Friedenreich CM, Quinney HA, Fields LA, Jones LW, Vallance JKH, Fairey AS. A Longitudinal Study of Exercise Barriers in Colorectal Cancer Survivors Participating in a Randomized Controlled Trial. Ann Behav Med 2005;29(2):147–153.
16. Campbell KL, Westerlind KC, Harber VJ, Friedenreich CM, Courneya KS. Association Between Aerobic Fitness and Estrogen Metabolites in Premenopausal Women. Med Sci Sports Exerc 2005; 37(4):585-92.
17. Csizmadi I , Friedenreich CM , Bryant HE, Courneya KS. An Analysis of the Effect of Selection Bias on the Association of Hormone Replacement Therapy and the Risk of Breast Cancer. Chronic Diseases in Canada 2005;26:73-79.
18. Tehard B, Friedenreich CM, Oppert JM, Clavel-Chapelon F. Effect of Physical Activity on Women at Increased Risk of Breast Cancer: Results from the E3N cohort study. Cancer Epidemiol Biomarkers Prev 2006;15(1):57-64.
19. Suijkerbuijk KPM, Van Duijnhoven FJ, Van Gils CH, Van Noord PAH, Peeters PHM, Friedenreich CM, Monninkhof EM. Physical Activity in Relation to Mammographic Density in the Dutch Prospect-EPIC cohort. Cancer Epidemiol Biomarkers Prev 2006;15(3):456-460.
20. Friedenreich CM , Courneya KS, Neilson HK, Matthews CE, Willis G, Irwin ML, Troiano R, Ballard-Barbash R. Reliability and Validity of the Past Year Total Physical Activity Questionnaire . Am J Epidemiol 2006;163:959-970.
21. Pischon T, Lahmann P, Boeing H, Friedenreich CM , Norat T, Tjonneland A, Halkjaer J, Overvad K, Clavel F, Bergmann M, Linseisen J, Becker N, Trichopoulou A, Trichopoulos D, Sieri S, Palli D, Tumino R, Vineis P, Panico S, Peeters P, BasBueno-de-Mesquita H, Boshuizen HC, van Guelpen B, Palmqvist R, Berglund G, Gonzalez CA, Dorronsoro M, Gurrea AB, Navarro C, Martinez C, Quiros JR, Roddam A, Allen N, Bingham S, Khaw K-T, Riboli E. Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation into Cancer and Nutrition. J Natl Cancer Inst 2006;98:920-931.
22. Steindorf K, Friedenreich CM , Linseisen J, Rohrmann S, Rundle A, Veglia F, Vineis P, Johnsen NF, Tjønneland A, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Boutron-Ruault M-C, Schulz M, Boeing H, Trichopoulou A, Kalapothaki V, Koliva M, Krogh V, Palli D, Tumino R, Panico S, Monninkhof E, Peeters PH, Boshuizen HC, Bas Bueno-de-Mesquita H, Chirlaque M-D, Agudo A, Larrañaga N, Quiros JR, Martinez C, Barricarte A, Janzon L, Gerglund G, Bingham S, Khaw K-T, Key TJ, Norat T, Jenab M, Cust A , Riboli E. Physical Activity and Lung Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort . Cancer Epidemiol Biomarkers Prev 2006;119(10):2389-97.
23. Bryant HE, Robson PJ, Ullman R, Friedenreich CM , Dawe U. Population-Based Cohort Development in Canada: A Feasibility Study . Chronic Diseases in Canada, 2006;27(2):55-63.
24. Friedenreich C, Norat T, Steindorf K, Boutron-Ruault M-C, Pischon T, Mazuir M, Clavel-Chapelon F, Linseisen J, Boeing H, Bergman M, Johnsen NF, Tjønneland A, Overvad K, Mendez M, Quirós JR, Martinez C, Dorronsoro M, Navarro C, Gurrea AB, Bingham S, Khaw K-T, Allen N, Key T, Trichopoulou A, Trichopoulos D, Orfanou N, Krogh V, Palli D, Tumino R, Panico S, Vineis P, Bueno-de-Mesquita HB, Peeters P HM, Monninkhof E, Berglund G, Manjer J, Ferrari P, Slimani N, Kaaks R, Riboli E. Physical Activity and Risk of Colon and Rectal Cancers: the European Prospective Investigation into Cancer and Nutrition . Cancer Epidemiology Biomarkers & Prevention 2006;15(12):2398-407.
25. Lahmann PH, Friedenreich C , Schuit AJ, Salvini S, Allen NE, Key TJ, Khaw KT, Bingham S, Peeters PHM, Monninkhof E, Bueno-de-Mesquita HB, Wirfält E, Manjer J, Gonzales CA, Ardanaz E, Amiano P, Quirós JR, Navarro C, Martinez C, Berrino F, Palli D, Tumino R, Panico S, Vineis P, Trichopoulou A, Bamia C, Trichopoulos D, Boeing H, Schulz M, Linseisen J, Chang-Claude J,
Clavel-Chapelon F, Fournier A, Boutron-Ruault MC, Tjønneland A, Føns Johnson N, Overvad K, Kaaks R, Riboli E. Physical Activity and Breast Cancer Risk: The European Prospective
Investigation into Cancer and Nutrition (EPIC). Cancer Epidemiology Biomarkers & Prevention 2007;16(1):1-7.
26. Csizmadi I , Kahle L, Ullman R, Dawe U, Zimmerman T, Friedenreich CM , Bryant HE, Subar A. Adaptation and Evaluation of the National Cancer Institute’s Dietary History Questionnaire and Nutrient Database for Use in Canadian Populations. Public Health Nutr 2007;10:88-96.
27. Cust AE , Kaaks R, Friedenreich C, Bonnet F, Laville M, Lukanova A, Rinaldi S, Dossus L, Slimani N, Lundin E, Tjønneland A, Olsen A, Overvad K, Clavel-Chapelon F, Mesrine S, Joulin V, Linseisen J, Rohrmann S, Pischon T, Boeing H, Trichopoulos D, Trichopoulou A, Benetou V, Palli D, Berrino F, Tumino R, Sacerdote C, Mattiello A, Quirós JR, Mendez MA, Sánchez M-J, Larraňaga N, Tormo MJ, Ardanaz E, Bueno-de-Mesquita HB, Peeters PHM, van Gils CH, Khaw K-T, Bingham S, Allen N, Key T, Jenab M, Riboli E. Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Post-menopausal Women . J Clin Endocrinol Metab 2007 Jan;92(1):255-63. Epub 2006 Oct 24.
28. Friedenreich C , Cust A, Lahmann PH, Steindorf K, Boutron-Ruault M-C, Clavel-Chapelon F, Mesrine S, Linseisen J, Rohrmann S, Boeing H, Pischon T, Tjønneland A, Halkjær J, Overvad K, Mendez M, Redondo ML, Martinez Garcia C, Larrañaga N, Tormo M-J, Gurrea AB, Bingham S, Khaw K-T, Allen N, Key T, Trichopoulou A, Vasilopoulou E, Trichopoulos D, Pala V, Palli D, Tumino R, Mattiello A, Vineis P, Bas Bueno-de-Mesquita H, Peeters PHM, Berglund G, Manjer J, Lundin E, Lukanova A, Slimani N, Jenab M, Kaaks R, Riboli E. Anthropometric Factors and Risk of Endometrial Cancer: the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 2007;121:347-55.
29. Cust AE , Armstrong BK , Friedenreich CM , Slimani N, Bauman A. Physical Activity and Endometrial Cancer Risk: A Review of the Current Evidence, Biologic Mechanisms and the Quality of Physical Activity Assessment Methods. Cancer Causes Control 2007;18:243-58.
30. Cust AE , Kaaks R, Friedenreich C , Bonnet F, Laville M, Lukanova A, Rinaldi S, Dossus L, Slimani N. Prediagnostic Plasma Adiponectin Levels and Endometrial Cancer Risk in the EPIC Cohort. J Clin Endocrinol Metab 2007;92:255-63.
31. Cust AE , Allen NE, Rinaldi S, Dossus L, Friedenreich C , Olsen A, Tjønneland A, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Linseisen J, Chang-Claude J, Boeing H, Schulz M, Benetou V, Trichopoulou A, Trichopoulos D, Palli D, Berrino F, Tumino R, Mattiello A, Vineis P, Quirós JR, Agudo A, Sánchez M-J, Larrañaga N, Navarro C, Ardanaz E, Bueno-de-Mesquita HB, Peeters PH, van Gils CH, Bingham S, Khaw KT, Key T, Slimani N, Riboli E, Kaaks R. Serum Levels of C-peptide, IGFBP-1, IGFBP-2 and Endometrial Cancer Risk; Results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2007;120:2656-64.
32. Friedenreich C , Cust A, Lahmann PH, Steindorf K, Boutron-Ruault M-C, Clavel-Chapelon F, Mesrine S, Linseisen J, Rohrmann S, Pischon T, Schulz M, Tjønneland A, Johnsen NF, Overvad K, Mendez M, Arguelles MV, Garcia CM, Larrañaga N, Chirlaque M-D, Ardanaz E, Bingham S, Khaw K-T, Allen N, Key T, Trichopoulou A, Dilis V, Trichopoulos D, Pala V, Palli D, Tumino R, Panico S, Vineis P, Bas Bueno-de-Mesquita H, Peeters PHM, Monninkhof E, Berglund G, Manjer J, Slimani N, Ferrari P, Kaaks R, Riboli E. Physical Activity and Risk of Endometrial Cancer: the European Prospective Investigation into Cancer and Nutrition. Cancer Causes and Control 2007;121:347-55.
33. Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM , Ladha AB, Proulx C, Vallance JK, Lane K, Yasui Y, McKenzie DC . Effects of Aerobic and Resistance Exercise in Breast Cancer Patients Receiving Adjuvant Chemotherapy: A Multicentre Randomized Controlled Trial. J Clin Oncol 2007;25:4396-4404.
34. Ferrari P, Friedenreich C , Matthews CE. The Role of Measurement Error in Estimating Levels of Physical Activity. Am J Epidemiol 2007;166:832-40.
35. Neilson HK, Robson PJ, Friedenreich CM , Csizmadi I . Estimating Energy Expenditure From Activity: How Valid are Physical Activity Questionnaires? Am J Clin Nutr. 2008 Feb;87(2):279-91.
36. Cust A , Kaaks R, Friedenreich CM , Bonnet F, Laville M, Tjønneland A, Olsen A, Overvad K, Jakobsen M, Chajès V, Clavel-Chapelon F, Boutron-Ruault M-C, Linseisen J, Lukanova A, Boeing H, Pischon T, Trichopoulou A, Christina B, Trichopoulos D, Palli D, Berrino F, Panico S, Tumino R, Sacerdote C, Torhild Gram I, Lund E, Quirós JR, Martinez-Garcia C, Chirlaque M-D, Ardanaz E, Berglund G, Lundin E, Bueno-de-Mesquita HB, van Duijnhoven FJB, Peeters P, Bingham S, Khaw K-T, Allen N, Key T, Ferrari P, Rinaldi S, Slimani N, Riboli E. Metabolic Syndrome, Plasma Lipid, Lipoprotein and Glucose Levels, and Endometrial Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Endocrine-Related Cancer 2007 (in press).
37. Courneya KS, Friedenreich CM . Physical Activity and Cancer Control: An Overview and Update. Seminars in Oncology Nursing 2007;23:242-52.
38. Courneya KS, Segal RJ, Gelmon K, Reid RD, Mackey JR, Friedenreich CM , Proulx C, Lane K, Ladha AB, Vallance JK, Liu Q, Yasui Y, McKenzie DC. Six-month Follow-up of Patient-rated Outcomes in a Randomized Controlled Trial of Exercise Training during Breast Cancer Chemotherapy. Cancer Epidemiol Biomarkers Prev 2007; 16:2572-2578.
39. Courneya KS, McKenzie DC, Mackey JR, Gelmon K, Reid RD, Friedenreich CM , Ladha AB, Proulx C, Vallance JK, Lane K, Yasui Y, Segal RJ. Moderators of the Effects of Exercise Training in Breast Cancer Patients Receiving Chemotherapy: Results from the START Trial. Cancer, (in press).
40. Courneya K, McKenzie DC, Reid RD, Mackey JR, Gelmon K, Friedenreich CM , Ladha AB, Proulx C, Lane K, Vallance JK, Segal RJ. Barriers to Supervised Exercise Training in a Randomized Controlled Trial of Breast Cancer Patients Receiving Chemotherapy. Annals Behavior Medicine 2008;35:116-122.
41. Emaus A, Furberg A-S, Veierød, Espetvedt S, Friedenreich CM , Ellison P, Jasienska G, Andersen LB, Thune I. Leisure Time Physical Activity, Heart Rate, Clustered Metabolic Risk Factors, and 17-β-Estradiol in Premenopausal Women. Med Sci Sports Exerc (in press).
42. Courneya K, Segal R, Gelmon K, Reid R, Mackey J, Friedenreich CM, Proulx C, Lane K, Ladha A, Vallance J, McKenzie D. Predictors of Adherence to Supervised Exercise Training During Breast Cancer Chemotherapy . Med Sci Sports Exerc (in press).
43. Friedenreich CM , Cust AE . Physical Activity and Breast Cancer: Impact of Timing, Type and Dose of Activity and Population Sub-group Effects. Br J Sports Med (in press).
44. Courneya KS, Friedenreich CM , Reid RD, Gelmon K, Mackey JR, Ladha AB, Proulx C, Vallance JK, Segal RJ. Predictors of Exercise Behavior at Six-Month Follow-Up After a Randomized Trial of Exercise Training During Breast Cancer Chemotherapy Breast Cancer Res Treat (in press).
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