Dr., Karen , Kopciuk
Dr. Karen Kopciuk - Alberta Cancer Board
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Dr. Karen Kopciuk
Research Scientist
Population Health Research
Alberta Health Services – Cancer Care
Tom Baker Cancer Centre
1331 – 29th Street N. W.
Calgary, Alberta T2N 4N2
Email: karen.kopciuk@albertahealthservices.ca
Current Appointments
| Research Scientist |
Population Health Research
Alberta Health Services Board
Calgary, Alberta |
| Adjunct Assistant Professor |
Department of Mathematics and Statistics
Faculty of Science, and
Department of Oncology,
Faculty of Medicine
University of Calgary,
Calgary, Alberta |
| Full member |
Southern Alberta Cancer Research Institute |
| Scientific staff |
Tom Baker Cancer Centre
Alberta Health Services - Cancer Care
Calgary, Alberta |
Education and Training
|
2003 |
PDF |
Samuel Lunenfeld Research Institute of Mount Sinai Hospital
Toronto, Ontario |
|
2001 |
Ph.D. |
Statistics
University of Waterloo
Waterloo, Ontario |
|
2001 |
Certificate |
University Teaching
University of Waterloo
Waterloo, Ontario |
|
1995 |
M.Math |
Statistics
University of Waterloo
Waterloo, Ontario |
|
1994 |
B.Sc. |
Statistics
University of Calgary
Calgary, Alberta |
|
1992 |
B.Sc. (Hons) |
Psychology
University of Calgary
Calgary, Alberta |
Overview of Research Program
Dr. Kopciuk's research interests include developing statistical methodology for processes that change over time, designing studies that utilize high throughput technology and creating new methods of analysis for data obtained from these studies and experiments. Developing practical and relevant methodology for chronic diseases is a central theme of her research.
Dr. Kopciuk’s current research projects illustrate this theme:
- developing methods for estimating the penetrance function of a major gene when there is missing genotype information, residual familial correlation and possible ascertainment bias;
- determining when an age-at-onset phenotype is more efficient than other longitudinal outcomes for detecting a linkage signal;
- developing methods for assessing gene expression data when the purpose is to show equivalences not differences; and
- extending methods for incomplete life history data and multi-state models to correlated data settings and with application to complex diseases;
- combining metabolomic data collected from different platforms; and
- evaluating the impact of measurement error on the detection of gene-environment interactions underlying complex diseases.
Currently Held Research Support
|
Agency |
Project Title |
Investigators |
Total Funding |
Term |
| CIHR |
Statistical methods and study designs for penetrance estimation of genes involved in complex diseases |
L Briollais (Co-PI)
KA Kopciuk (Co-PI)*
J McLaughlin |
$196,050 |
2003-2006 |
|
CBCF |
Beta retrovirus and breast cancer: serologic and genetic markers of infection |
J Mackey
HE Bryant*
C Cass
S Damaraju
R Greiner
K Kopciuk*
A Mason |
$163,000 |
2004-2006 |
| NSERC |
Longitudinal phenotype choice for complex traits in genetic analyses of family data |
K Kopciuk* |
$24,000 |
2004-2007 |
| CIHR |
Cohort study of physical activity and prostate cancer survival: Continuation of follow-up |
CM Friedenreich*
S Angyalfi
KS Courneya
F Elliott
K Kopciuk*
SE McGregor* |
$283,453 |
2004-2007 |
| CBCF |
Novel genetic markers of breast cancer risk |
J Mackey
HE Bryant*
C Cass
S Damaraju
R Greiner
K Kopciuk* |
$189,438 |
2004-2006 |
|
ACB |
Cohort study of physical activity and prostate cancer survival: Continuation of follow-up |
CM Friedenreich*
S Angyalfi
KS Courneya
F Elliott
K Kopciuk*
SE McGregor* |
$40,244 |
2004-2007 |
ACB
|
Population Health Research Unit, Division of Population Health and Information |
HE Bryant*
CM Friedenreich*
SE McGregor*
LS Cook*
P Brasher*
K Kopciuk*
I Csizmadi* |
$340,000 |
2004-2007 |
| ACF |
The Alberta Cohort Study (The Tomorrow Project): Infrastructure Support |
HE Bryant*
CM Friedenreich*
SE McGregor*
I Csizmadi*
K Kopciuk*
LS Cook*
P Robson* |
$498,626 |
2005-2006 |
|
ACF |
Individual, social and environmental determinants of physical activity in an Alberta cohort |
HE Bryant*
K Kopciuk*
CM Friedenreich*
R Plotnikoff |
$19,696 |
2006-2008 |
| ACB |
Evaluation of chemoresponsiveness as a function of stromal and tumour molecular signatures |
O Bathe
A Magliocco
M Arcellana-Panlilio*
K Kopciuk* |
$35,000 |
2006 |
| Pacific Institute for the Mathematical Sciences |
Research group in statistical genomics |
K Kopciuk* |
$25,000 |
2006-2008 |
| ACF |
The Alberta Cohort Study (The Tomorrow Project): Infrastructure Support |
P Robson*
HE Bryant*
CM Friedenreich*
SE McGregor*
I Csizmadi*
K Kopciuk*
L Cook* |
$1,293,653 |
2006-2007 |
| CIHR |
Interdisciplinary research on the determinants and impact of colorectal cancer: molecular-genetic factors, risk modifiers and pupulation health |
J McLaughlin
PS Parfrey
HB Younghusband
S Gallinger
PP Wang
RC Green
M Cotterchio
E Holowaty
MJ Esplen
K Kopciuk*
et al |
$4,951,888 |
2006-2011 |
| ACF |
Population Health Research Unit, Division of Population Health and Information |
CM Friedenreich*
HE Bryant*
L Cook*
SE McGregor*
K Kopciuk*
I Cismadi* |
$1,254,525 |
2007-2010 |
| ACF |
The Alberta Cohort Study (The Tomorrow Project): Infrastructure Support |
P Robson*
HE Bryant*
CM Friedenreich*
SE McGregor*
I Csizmadi*
K Kopciuk*
N Brockton*
L Kelemen* |
$1,203,262 |
2007-2008
|
| NSERC |
Statistical methods for chronic diseases with genetic determinants |
K Kopciuk* |
$16,000 |
2007-2009 |
| ACRI |
Assessing the impact of tumour heterogeneity on genetic signatures for colorectal cancer liver metastases |
M Arcellana-Panlilio
K Kopciuk (Co-PI)*
O Bathe |
$273,054 |
2008-2011 |
| ACRI |
Targetting multiple myeloma with oncolytic viral therapy |
D Morris
K Kopciuk*
C Thirukkumaran |
$449,981 |
2008-2011 |
| CIHR |
Development of a multidimensional measure of activity energy expenditure for use in large populations. |
I Csizmadi*
P Robson*
HE Bryant*
CM Friedenreich*
P Jones
K Kopciuk*
D Lau
Y Yasui |
$249,454 |
2008-2010 |
| CBCF/ACRI |
Patient genotype in the development of rapid skeletal metastasis in breast cancer |
D Demetrick
K Kopciuk (Co-PI)*
T Trotter |
$257,853 |
2008-2010 |
| ACRI |
Division of Population Health and Information; Priority Funding Request 2007 |
CM Friedenreich*
K Kopciuk*
L Kelemen*
N Brockton* |
$418,335 |
2008-2011 |
| ACRI - Top up grant |
Development of a multidimensional measure of activity energy expenditure for use in large populations. |
I Csizmadi*
P Robson*
HE Bryant*
CM Friedenreich*
P Jones
K Kopciuk*
D Lau
Y Yasui |
$29,001 |
2008-2010
|
| AHFMR - Visiting Lecturer Award |
Visiting Lecturer support. |
C Friedenreich*
K Kopciuk* |
$7,825 |
2008 |
| ACRI |
PHRU Priority Funding Request 2009-2012 |
CM Friedenreich*
SE McGregor*
K Kopciuk*
R Hilsden
L Kelemen*
T Magliocco
N Brockton* |
$3,386,032 |
2009-2012 |
| ACRI |
Development of a test for pancreatic and periampullary malignancies based on metabolomics |
O Bathe (Co-PI)
H Vogel (Co-PI)
K Kopciuk*
A Weljie
F Sutherland
F Dixon
C Turbide
J Love
S Heitman
S Bass
M Cole
D Lau |
$378,434 |
2009-2012 |
Recent Publications (2005-present)
Kopciuk KA, Choi Y-H, Parkhomenko E, Parfrey P, McLaughlin JR, Green J, Briollais L. Penetrance of HNPCC-related cancers in a retrolective cohort of 12 large Newfoundland families carrying a MSH2 founder mutation: an evaluation using modified segregation models in HNPCC families.
Friedenreich CM, Gregory J, Kopciuk KA, Mackey JM, Courneya KS. Prospective Cohort Study of Lifetime Physical Activity and Breast Cancer Survival. International Journal of Cancer 2009; 124 (8):1954-1962.
Sun J, Kopciuk KA, Lu X. Polynomial Spline Estimation of Partially Linear Single-Index Proportional Hazards Regression Models. Computational Statistics & Data Analysis 2008; 53(1):176-188.
Choi Y-H, Kopciuk KA, Briollais L. Bias and Efficiency in Family-based Designs for Estimating the Risk Associated with Mutated Genes Involved in Complex Diseases. Human Heredity 2008; 66:238-251.
Kopciuk KA, Bryan J, Arcellana-Panlilio M. Status of Statistical Genomics Research in Canada. Third Annual Canadian Genetic Epidemiology & Statistical Genetics Meeting. April 29 - May 1, 2008, Fields Institute, Toronto, ON.
Nottage MK, Kopciuk KA, Tzontcheva A, Andrulis IL, Bull SB, Blackstein ME. Analysis of incidence and prognostic factors for ipsilateral breast tumour recurrence and its impact on disease-specific survival of women with node-negative breast cancer: a prospective cohort study. Breast Cancer Research 2006, 8:R44.
Kopciuk KA. Odds ratio estimators for small samples or zero cells. Biostats Corner, Canadian Society for Epidemiology and Biostatistics Bulletin. Spring/Summer 2006.
Kopciuk KA and Bull SB. (2005). Genetic Risk Ratios. In Armitage and Colton, eds. Encyclopedia of Biostatistics, second edition. Toronto: John Wiley & Sons.
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